Everglades City sits on one end of the Wilderness Waterway, the famous 99-mile Everglades backcountry route linking Everglades City to Flamingo on the east side of Florida. This outpost makes an ideal place to base your vacation forays into Big Cypress National Preserve, Everglades National Park, Fakahatchee Strand Preserve State Park, and Collier-Seminole State Park.